Pharmaceutical with predetermined activity profile

US6458384B2 · kind B2 · utility

Assignee

• IMPETUS LLC · US

Inventors

• Christof Jaenicke · Berlin, DE
• Jorg Grunwald · Dinslaken, DE
• Benedikt Hänggi · Arlesheim, CH

Key dates

• Filing date: Feb 23, 2001
• Grant date: Oct 1, 2002
• Expiry date: Feb 23, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K36/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A first pharmacologically active substance contained in a pharmaceutical, which acts on a specific biological function, is released according to a predetermined release profile (D.1), FIG. 1, and generates a first activity profile (I.1) that has flank phases with increasing and decreasing activity intensity. For changing such flank phases, an additional pharmacologically active substance is used which acts on the same biological function and which is released according to a release profile (D.2) such that its activity profile (I.2) overlays the first activity profile (I.1) within the flank phase to be changed. For shortening an end flank phase, an additional substance is used whose activity is counter to the activity of the first substance and cancels, reduces, or overpowers this activity in its declining phase. Accordingly, with the aforementioned pharmaceutical, undesirable aftereffects of a pharmacologically active substance, for example, can be prevented. In one embodiment, a sedative is contained as a first pharmacologically active substance, which is released immediately, and a stimulant, which is released with delay and thus counteracts uncomfortable aftereffects of the seda…