Metalloprotease peptide substrates and methods
US6458552B1 · kind B1 · utility
4Cited by
1References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 6, 2000 |
| Grant date | Oct 1, 2002 |
| Priority date | — |
| Expiry date | Jun 28, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/573
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention describes peptide substrates of the metalloproteases, ADAM8, ADAM15 and MDC-L. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases. The invention further describes CD23 processing activity for these enzymes that may have important therapeutic implications for the use of inhibitors of these enzymes in allergic diseases such as asthma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.