Halovir, an antiviral marine natural product, and derivatives thereof

US6458766B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• William Fenical · Del Mar, US
• Paul Jensen · San Diego, US
• David C. Rowley · Wakefield, US

Key dates

• Filing date: Dec 15, 1998
• Grant date: Oct 1, 2002
• Expiry date: Dec 15, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: whereinR1a and R1b are independently selected from the group consisting of —H, alkyl, lower-alkyl, substituted alkyl and substituted lower-alkyl;R2a and R2b are independently selected from the group consisting of —H, lower-alkyl, and substituted lower-alkyl;R3 is —H, lower-alkyl, substituted lower-alkyl and where R3 and R4 are attached together by a lower-alkyl or a substituted lower-alkyl moiety;R4 is —H, lower-alkyl, substituted lower-alkyl and where R3 and R4 are attached together form a lower-alkyl or substituted lower-alkyl bridge;R5, R7, R9 and R11 are independently selected from the group consisting of —H, lower-alkyl, and substituted lower-alkyl;R6 is —H, lower-alkyl and substituted lower-alkyl;R8 is —H, lower-alkyl and substituted lower-alkyl;R10 is —H, lower-alkyl and substituted lower-alkyl;R12 is —H, lower-alkyl and substituted lower-alkyl; andA is —C(O)—R13, wherein R13 is —H, —OH, alkyl, lower-alkyl, substituted lower-alkyl or —O(lower-alkyl); —CH2—OR14 wherein R14 is —H, —C(O)CH3, alkyl, lower-alky…