Prodrugs

US6458772B1 · kind B1 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Xiao-Xiong Zhou · Huddinge, SE
• Nils-Gunnar Johansson · Huddinge, SE
• Horst Wahling · Huddinge, SE
• Christian Sund · Bethesda, US
• Hans Wallberg · Stuvsta-Snättringe, SE
• Lourdes Salvador · Norrköping, SE
• Stefan Lindstrom · Huddinge, SE
• Christer Sahlberg · Stuvsta-Snättringe, SE

Key dates

• Filing date: Feb 12, 1999
• Grant date: Oct 1, 2002
• Expiry date: Feb 12, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I or corresponding monohydroxynucleoside derivatives wherein:R1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon;a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid;R2 is the residue of an aliphatic L-amino acid;L1 is a trifunctional linker group;L2 is absent or a difunctional linker group;and pharmaceutically acceptable salts thereof have favorable pharmacological properties and are antivirally active.