Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase

US6458783B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Charles Z. Ding · San Mateo, US
• John T. Hunt · Princeton, US
• Katerina Leftheris · Skillman, US
• Rajeev S. Bhide · Princeton Junction, US

Key dates

• Filing date: Apr 21, 2000
• Grant date: Oct 1, 2002
• Expiry date: Apr 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof.