Substituted piperidines as melanocortin receptor agonists

US6458790B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Brenda Palucki · Fryeburg, US
• Khaled Barakat · Brooklyn, US
• Liangqin Guo · Edison, US
• Yingjie Lai · Edison, US
• Ravi Nargund · East Brunswick Township, US
• Min K. Park · Whippany, US
• Patrick G. Pollard · Oakhurst, US
• Iyassu Sebhat · Jersey City, US
• Zhixiong Ye · Princeton, US

Key dates

• Filing date: Mar 20, 2001
• Grant date: Oct 1, 2002
• Expiry date: Mar 20, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment and control of obesity, diabetes, and sexual dysfunction, including erectile dysfunction and female sexual dysfunction.