Modified prodrug forms of AP/AMP

US6458816B1 · kind B1 · utility

Assignee

• Vion Pharmaceuticals, Inc. · US

Inventors

• Terrence W. Doyle · Fayetteville, US
• Srinivasa Karra · Pembroke, US
• Zujin Li · Orange, US
• Xu Lin · Branford, US
• John Mao · San Bruno, US
• Qi Qiao · San Diego, US
• Yang Xu · Wenhe, CN

Key dates

• Filing date: Oct 15, 2001
• Grant date: Oct 1, 2002
• Expiry date: Oct 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds according to the structure: WhereR is H or CH3;R2 is phosphate which can be free acid or salt;R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group;R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; andR5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.