Myotilin, a novel actin-organizing protein
US6458929B1 · kind B1 · utility
2Cited by
1References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 16, 1999 |
| Grant date | Oct 1, 2002 |
| Priority date | — |
| Expiry date | Jul 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns a novel cytoskeletal protein, myotilin, which contains Ig-like domains homologous to a giant sarcomeric structural protein titin. Myotilin is expressed in skeletal and cardiac muscles, it colocalizes with &agr;-actinin in the sarcomeric I-bands and directly interacts with &agr;-actinin. Expression of myotilin in mammalian non-muscle cells and in yeast causes reorganization of actin into thick F-actin bundles and inhibits growth of yeast cells.
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