Process for preparation of pharmaceutically desired enantiomers
US6458955B1 · kind B1 · utility
6Cited by
4References
4Claims
0Family size
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Key dates
| Filing date | Nov 3, 2000 |
| Grant date | Oct 1, 2002 |
| Priority date | — |
| Expiry date | Nov 3, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer is racemized and recycled to the resolution phase to avoid loss.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.