Naphthalene ureas as glucose uptake enhancers

US6458998B1 · kind B1 · utility

Assignee

• Telik, Inc. · US

Inventors

• Wayne Spevak · Berkeley, US
• Songyuan Shi · Fremont, US
• Prasad Manchem · South San Francisco, US
• Michael R. Kozlowski · Palo Alto, US
• Steven R. Schow · Washingtonville, US
• Robert T. Lum · Palo Alto, US

Key dates

• Filing date: May 25, 2000
• Grant date: Oct 1, 2002
• Expiry date: May 25, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4021
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.