Parallel liquid chromatography for analyzing combinatorial libraries of non-biological polymers
US6461515B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 28, 2000 |
| Grant date | Oct 8, 2002 |
| Priority date | — |
| Expiry date | Nov 28, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method is disclosed for characterizing non-biological polymers using liquid chromatography that is particularly useful in polymer research programs. The method includes the steps of providing a library of four or more non-biological polymer samples, with each of the four or more polymer samples being polymerization product mixtures that result from polymerization reactions that are varied with respect to a factor affecting polymerization. Each of the four or more polymer samples resides in the reaction vessel in which they were formed. The method further includes sampling first and second polymer samples from the reaction vessels in which they were formed, supplying a mobile phase in parallel through each of a first chromatographic column and a second chromatographic column of a liquid chromatography system, injecting the first and second polymer samples into the mobile phase of the first and second chromatographic columns, respectively, simultaneously separating at least one sample component of the injected first and second samples from other sample components thereof in the respective chromatographic columns, and detecting a property of at least one of the separated sample comp…
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