Recombinant &agr;-galactosidase a therapy for Fabry disease
US6461609B1 · kind B1 · utility
31Cited by
3References
7Claims
0Family size
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Key dates
| Filing date | Jan 29, 1997 |
| Grant date | Oct 8, 2002 |
| Priority date | — |
| Expiry date | Jan 29, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fabry disease results from an X-linked deficiency in the enzyme &agr;-galactosidase A. The present invention is directed to recombinant human &agr;-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of &agr;-galactosidase A are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.