Androgen receptor modulator compounds and methods

US6462038B1 · kind B1 · utility

Assignee

• Ligand Pharmaceuticals Incorporated · US

Inventors

• Robert I. Higuchi · Solana Beach, US
• Kristen L. Arienti · San Diego, US
• Mani Neelakandha · San Diego, US
• Barbara Pio · West Orange, US
• Lin Zhi · San Diego, US
• Penghui Chen · Tianjin, CN
• Thomas Raymond Caferro · Abington, US

Key dates

• Filing date: Aug 25, 2000
• Grant date: Oct 8, 2002
• Expiry date: Aug 25, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.