Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors
US6462048B2 · kind B2 · utility
5Cited by
4References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 24, 1998 |
| Grant date | Oct 8, 2002 |
| Priority date | — |
| Expiry date | Sep 24, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/86
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to lactam derivatives of the formula wherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1D receptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT1 agonist or antagonist is indicated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.