Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group

US6462055B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Jonathan Bloom · Hartsdale, US
• Kevin Joseph Curran · Nyack, US
• Martin DiGrandi · Piermont, US
• Russell Dushin · Old Lyme, US
• Stanley Lang · Carlsbad, US
• Emily Norton · Nanuet, US
• Adma Ross · Suffern, US
• Bryan O'Hara · Norwood, US

Key dates

• Filing date: Apr 30, 2001
• Grant date: Oct 8, 2002
• Expiry date: Apr 30, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C335/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the formula: whereinR1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R1 and R2 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl;R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, orR7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl;W is O, NR6, or is absent;Y is —(CO)— or —(CO2)—, or is absent;Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, &…