Method for converting sparingly water-soluble medical substance to amorphous state
US6462093B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1998 |
| Grant date | Oct 8, 2002 |
| Priority date | — |
| Expiry date | Feb 6, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/146
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for producing a solid dispersion of a sparingly water-soluble medical substance which comprises subjecting the sparingly water-soluble medical substance, an amorphous state-inducing agent and an amorphous state-stabilizing agent to heat treatment or mechanochemical treatment; anda process for producing a solid dispersion of a sparingly water-soluble medical substance which comprises high-frequency heating the sparingly water-soluble medical substance and an amorphous state-stabilizing agent. These processes make it possible to make sparingly water-soluble medical substance amorphous at a temperature lower than those employed in the conventional methods. The solid dispersions of the armorphous sparingly water-soluble medical substances thus obtained have an improved mucosal or rectal absorption rate, which makes it possible to elevate their bioavailability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.