Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US6462171B1 · kind B1 · utility
25Cited by
6References
16Claims
0Family size
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Key dates
| Filing date | Dec 12, 1996 |
| Grant date | Oct 8, 2002 |
| Priority date | — |
| Expiry date | Dec 12, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel peptides capable of interacting with a hydrophobic &bgr;-sheet forming cluster of amino acid residues on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits and into pathological &bgr;-sheet-rich conformation as precursors thereof. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.