Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
US6464895B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 1, 1998 |
| Grant date | Oct 15, 2002 |
| Priority date | — |
| Expiry date | Dec 1, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function, or for the synthesis of oxysulphide-containing and fluorine-containing organic derivatives, wherein said reagent comprises:a) a fluorocarboxylic acid of formula Ew—CF2—COOH where Ew represents an electron-withdrawing atom or group, at least partially salified with an organic or inorganic cation, andb) a polar aprotic solvent;and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid.A synthetic process uses this reagent by heating in order to graft a substituted difluoromethyl group onto various compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.