Treating medical conditions by polymerizing macromers to form polymeric materials

US6465001B1 · kind B1 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jeffrey A. Hubbell · Austin, US
• Chandrashekhar P. Pathak · Austin, US
• Amarpreet S. Sawhney · Lexington, US
• Neil P. Desai · Los Angeles, US
• Syed F. A. Hossainy · Fremont, US
• Jennifer L. Hill-West · Pasadena, US

Key dates

• Filing date: Mar 3, 1998
• Grant date: Oct 15, 2002
• Expiry date: Mar 3, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2989
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, and coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules. A medical condition at a localized site is treated by applying a polymerization initiator and then applying a substantially water-soluble, degradable macromer of at least 200 mw and having at least two crosslinkable substituents, and polymerizing the macromer to form a crosslinked polymeric material at the site. The crosslinked polymeric material may adhere two surfaces together, or be a barrier that provides immunoisolation or prevents adhesion of the site to another surface such as post-surgical adhesion. A biologically active material may be present when the macromer is polymerized to provide …