Reagents and methods useful for detecting diseases of the prostate

US6465181B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Patricia Billing-Medel · Gurnee, US
• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Julian Gordon · Lake Bluff, US
• Edward Granados · Vernon Hills, US
• John Russell · Pleasant Prairie, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: Mar 25, 1999
• Grant date: Oct 15, 2002
• Expiry date: Mar 25, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/136
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.