Non-human carbonyl hydrolase mutants, DNA sequences and vectors encoding same and hosts transformed with said vectors
US6465235B1 · kind B1 · utility
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48Claims
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Key dates
| Filing date | Dec 18, 1997 |
| Grant date | Oct 15, 2002 |
| Priority date | — |
| Expiry date | Dec 18, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/07
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant carbonyl hydrolase to encode the substitution, insertion or deletion of one or more amino acids in the amino acid sequence of a precursor carbonyl hydrolase. Such mutants have one or more properties which are different than the same property of the precursor hydrolase.
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