Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

US6465467B1 · kind B1 · utility

Assignee

• Biovitrum AB · SE

Inventors

• Bjorn Nilsson · Foster City, US
• Jan Tejbrant · Stuvsta-Snättringe, SE
• Benjamin Pelcman · Stockholm, SE
• Erik Ringberg · Uppsala, SE
• Markus Thor · Knivsta, SE
• Jonas Nilsson · Lindome, SE
• Mattias Jonsson · Uppsala, SE

Key dates

• Filing date: Jun 8, 2000
• Grant date: Oct 15, 2002
• Expiry date: Jun 8, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula (I):wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2 receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2c receptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.