Hydroxamic and carboxylic acid derivatives
US6465468B1 · kind B1 · utility
10Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 22, 2000 |
| Grant date | Oct 15, 2002 |
| Priority date | — |
| Expiry date | Mar 22, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF &agr; or a condition involving a membrane-shedding event that is mediated by a metalloproteinase. Compounds of the invention are of formula I(B)2N—X—(CH2)m—W—(CR1R2)n—COY  (I)whereinn=0 or 1;m=0 or 1;X is S(O)1-2;Y is OH or NHOH;W is aryl or heteroaryl;and the other groups are as defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.