Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression

US6465482B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Richard E. Mewshaw · King of Prussia, US
• Ping Zhou · Plainsboro, US
• Dahui Zhou · Groton, US
• Kristin Meagher · Thousand Oaks, US
• Magda Asselin · Mahwah, US
• Deborah Evrard · Hamilton Square, US
• Adam Matthew Gilbert · Congers, US

Key dates

• Filing date: Oct 3, 2001
• Grant date: Oct 15, 2002
• Expiry date: Oct 3, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein:R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring;R4 is hydrogen, halogen, or alkyl;R5 is hydrogen, alkyl, alkylaryl, or aryl;R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy;X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen;Y is carbon or nitrogen; andZ is carbon or nitrogen; orpharmaceutically acceptable salts thereof.