Pyridyl/quinolinyl imidazoles

US6465486B1 · kind B1 · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Ellen W. Baxter · Glenside, US
• Robert E. Boyd · Horsham, US
• John R. Carson · Norristown, US
• Michele C. Jetter · Norristown, US
• Allen B. Reitz · Lansdale, US

Key dates

• Filing date: Mar 10, 2000
• Grant date: Oct 15, 2002
• Expiry date: Mar 10, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/47
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain imidazo pyridines/quinolines of the formula: wheren is 0, 1, 2;X is independently selected from the group consisting of C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2, nitro, and two adjacent X may be fused to form the moiety:  whereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed;Y is independently selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, trifluoromethyl and phenyl; andZ is independently selected from the group consisting of hydroxy, C1-4alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4alkoxy, —SO2NH2 and nitro;are &agr;2-adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.