Arylthiazolidinedione derivatives

US6465497B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Ranjit C. Desai · Colonie, US
• Soumya P. Sahoo · Old Bridge, US
• Jeffrey P. Bergman · Tenafly, US
• Victoria K. Lombardo · Montgomery, US
• Edward Metzger · Edison, US
• Hiroo Koyama · Westfield, US

Key dates

• Filing date: Nov 21, 2001
• Grant date: Oct 15, 2002
• Expiry date: Nov 21, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted 5-aryl-2,4-thiazolidinediones and oxazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR &agr; and/or &ggr; mediated diseases, disorders and conditions.