Latent reactive blood compatible agents
US6465525B1 · kind B1 · utility
45Cited by
13References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1998 |
| Grant date | Oct 15, 2002 |
| Priority date | — |
| Expiry date | Oct 22, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L33/0082
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.