Hydrophilic somatostatin analogs
US6465613B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1998 |
| Grant date | Oct 15, 2002 |
| Priority date | — |
| Expiry date | Nov 19, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features novel somatostatin analogs that may be readily labeled with toxic or non-toxic detectable labels. These unlabeled and labeled analogs are useful for specifically targeting somatostatin receptor bearing cells, in particular neoplastic cells. Labeled analogs are useful, for example, for tumor localization and detection. Where labeled with a toxic label (e.g., radioactivity), the analogs are useful for the targeted delivery of toxicity to somatostatin receptor-bearing cells, in particular neoplastic cells.Also disclosed are methods for treating and detecting neoplasms, and methods for imaging somatostatin receptor-bearing cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.