Synthesis of 1,3,5-trisubstituted pyrazoles

US6465656B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Jiacheng Zhou · Shanghai, CN
• Lynette Oh · West Chester, US
• Pasquale N. Confalone · Wilmington, US
• Hui Li · Santa Clara, US
• Philip Ma · Mountain View, US

Key dates

• Filing date: Dec 3, 2001
• Grant date: Oct 15, 2002
• Expiry date: Dec 3, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.