Method and device for producing pharmaceutical formulations containing an extract

US6468563B1 · kind B1 · utility

Assignee

• Lichter Pharma AG · DE

Inventors

• Peter C. Schmidt · Leverkusen, DE
• Karin Rocksloh · Kirchentellinsfurt, DE
• Wolfgang Muller · Königsfeld, DE
• Markus Reher · Glienicke, DE
• Salah Abu Abed · Berlin, DE

Key dates

• Filing date: Aug 28, 2000
• Grant date: Oct 22, 2002
• Expiry date: Aug 28, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2077
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing rapidly disintegrating pharmaceutical formulations containing an extract is provided. The process comprises providing a dry powdered extract and a lubricant, compacting the powdered extract with the lubricant, using between about 0.5-10% lubricant by weight. The compacting is done using a device that yields flakes. The flakes are then crushed into granules, and the granules are compressed with conventional excipients such as bulking agents, glidants, disintegrants, flow regulators and other additives into pharmaceutical formulations.