Process for the inactivation of viruses

US6468778B1 · kind B1 · utility

Assignee

• Aventis Behring GmbH · DE

Inventors

• Eckhard Schueler · Marburg, DE
• Gerhardt Kumpe · Wetter, DE
• Thomas Nowak · Staufenberg, DE

Key dates

• Filing date: May 17, 2000
• Grant date: Oct 22, 2002
• Expiry date: May 17, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/08
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A process for the inactivation and/or elimination of coated and/or noncoated viruses from a plasma protein solution by addition of an ammonium salt at alkaline pHs is described, in which a chromatographically prepurified plasma protein solution is subjected to an incubation at room temperature and at an ammonium salt concentration of 13 to 22% by weight, pasteurized at approximately 60° C. for several hours after separation of the precipitates and removal of the ammonium salt down to a residual content of less than 0.5 mol/l and then processed to give a therapeutically employable plasma protein preparation.