Expression of cloned genes in the lung by aerosol and liposome-based delivery
US6468798B1 · kind B1 · utility
141Cited by
19References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1998 |
| Grant date | Oct 22, 2002 |
| Priority date | — |
| Expiry date | Jan 30, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Liposome-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary cells, treat disorders of the lung, and for delivering substances systematically following expression in the lung.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.