Octacyclodepsipeptides having an endoparasiticidal action

US6468966B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Scherkenbeck · Leverkusen, DE
• Peter Jeschke · Eltville am Rhein, DE
• Hans-Georg Lerchen · Leverkusen, DE
• Hermann Hagemann · Leverkusen, DE
• Achim Harder · Leverkusen, DE
• Norbert Mencke · Leverkusen, DE
• Andrew Plant · Leverkusen, DE

Key dates

• Filing date: May 19, 1994
• Grant date: Oct 22, 2002
• Expiry date: May 19, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the general formula (I) in whichR1 and R12 represent the same or different radicals selected from the group of C2-9-alkyl, C1-8-halogen-alkyl, C3-6-cycloalkyl, aralkyl or aryl,R3 to R10 represent the same or different radicals selected from the group of hydrogen, C1-5-alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a —NR13R14 group in which R13 or R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C1-4-alkyl,R2 and R11 represent the same of different radicals selected from the group of C1-4-alkyl,and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.