Patent · US Expired

Active hedgehog protein conjugate

US6468978B1 · kind B1 · utility

5Cited by

1References

15Claims

0Family size

Assignee

Curis, Inc. · US

Inventors

Angelika Esswein · Büttelborn, DE
Kurt Lang · Penzberg, DE
Petra Rueger · Penzberg, DE
Tilman Seytter · Gräfelfing, DE

Key dates

Filing date	Apr 28, 1999
Grant date	Oct 22, 2002
Priority date	—
Expiry date	Apr 28, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.