Peptidyl heterocyclic ketones useful as tryptase inhibitors
US6469036B1 · kind B1 · utility
9Cited by
4References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2000 |
| Grant date | Oct 22, 2002 |
| Priority date | — |
| Expiry date | Jan 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.