Fluoro oxindole derivatives as modulators if KCNQ potassium channels

US6469042B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Piyasena Hewawasam · Middletown, US
• Pierre Dextraze · Elliot Lake, CA
• Valentin Gribkoff · Wallingford, US
• Gene Kinney
• Steven Dworetzky · Middlefield, US

Key dates

• Filing date: Feb 14, 2002
• Grant date: Oct 22, 2002
• Expiry date: Feb 14, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I whereinR1, R2, R3 and R4 each are independently hydrogen, C1-4 alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl;R5 is C1-6 alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R5 is not C1-6 alkyl when Y is O;Y is O or S; andR6 and R7 each are independently hydrogen, chloro, bromo or trifluoromethy;which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.