Patent · US Expired

Tramadol, salts thereof and process for their preparation

US6469213B1 · kind B1 · utility

3Cited by

5References

12Claims

0Family size

Assignee

Russinsky Limited · IE

Inventors

Helmut Schickaneder · Eckental, DE
Aggelos Nikolopoulos · Cork, IE

Key dates

Filing date	Jan 14, 2000
Grant date	Oct 22, 2002
Priority date	—
Expiry date	Jan 14, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydrochloride. Also claimed is the base hydrate of cis-Tramadol per se and its use as a medicament.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.