Method and composition for modulating amyloidosis

US6472145B2 · kind B2 · utility

Assignee

• University of British Columbia · CA

Inventors

• Peter B. Reiner · Vancouver, CA
• Bruce Connop · Vancouver, CA

Key dates

• Filing date: Jun 5, 2001
• Grant date: Oct 29, 2002
• Expiry date: Jun 5, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents which modulate APP catabolism and amyloid deposition. Accordingly, the methods and compositions are useful for inhibiting amyloidosis in disorders in which amyloid deposition occurs. The methods are based, at least in part, on modulating catabolism of APP in APP-containing cells through the use of a mobile ionophore, such as carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone, which does not substantially alter the viability of those cells.