Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
US6472436B1 · kind B1 · utility
15Cited by
4References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 2000 |
| Grant date | Oct 29, 2002 |
| Priority date | — |
| Expiry date | Jul 17, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing amyloid protein production in cells and methods of inhibiting cell death. Invention methods can be used to prevent and treat a diverse class of disease conditions, known as amyloidoses, which are all related to the occurrence of amyloid protein deposits. Invention methods further provide methods of identifying compounds that can block amyloid toxicity or block the amyloid protein induced inhibition of MMT reduction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.