Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus

US6475718B2 · kind B2 · utility

Assignees

• SCHERING CORPORATION · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Robert Doms · Berwyn, US
• Daryl Faulds · Mill Valley, US
• Joseph E. Hesselgesser · San Francisco, US
• Richard Horuk · Belmont, US
• Branislava Mitrovic · Walnut Creek, US
• Yiqing Zhou · Hong Kong, CN

Key dates

• Filing date: Sep 8, 1998
• Grant date: Nov 5, 2002
• Expiry date: Oct 21, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.