Pathogenic tau mutations

US6475723B2 · kind B2 · utility

Assignees

• Mayo Foundation for Medical Education and Research · US
• Washington University · US
• Erasmus Universiteit Rotterdam · NL
• The Victoria University of Manchester · GB

Inventors

• Michael L. Hutton · Newton, US
• Peter Heutink · Rotterdam, NL
• Alison M. Goate · Chesterfield, US
• Stuart Brown · Buxton, GB

Key dates

• Filing date: Apr 30, 1999
• Grant date: Nov 5, 2002
• Expiry date: Apr 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/4711
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.