Inhibition of angiogenesis by delivery of nucleic acids encoding anti-angiogenic polypeptides
US6475784B1 · kind B1 · utility
13Cited by
2References
5Claims
0Family size
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Key dates
| Filing date | Nov 13, 1998 |
| Grant date | Nov 5, 2002 |
| Priority date | — |
| Expiry date | Nov 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention provides polypeptides having anti-angiogenic activity and nucleic acids that encode these polypeptides. The anti-angiogenic polypeptides include at least kringles 1-3 of plasminogen. The invention also provides methods of using the polypeptides and nucleic acids for inhibiting angiogenesis and other conditions characterized by undesirable endothelial cell proliferation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.