Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C
US6475785B1 · kind B1 · utility
5Cited by
8References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1999 |
| Grant date | Nov 5, 2002 |
| Priority date | — |
| Expiry date | Aug 5, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4712
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to single-chain polypeptides and their genetic sequences comprising a human cardiac troponin I N-terminal fragment and troponin C. The N-terminal fragment may or may not have the intact N-terminus. The single-chain polypeptide may be expressed recombinantly, and a linker or spacer polypeptide or peptide may be interposed between the troponin sequences. The single-chain polypeptides have utility as controls or calibrators for troponin assays, for the purification of troponin subunits and as an antigen for the preparation of antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.