Oral delivery of nucleic acid vaccines by particulate complexes

US6475995B1 · kind B1 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Krishnendu Roy · Austin, US
• Shau-Ku Huang · Towson, US
• Hugh A. Sampson · Larchmont, US
• Kam W. Leong · Ellicott City, US

Key dates

• Filing date: Jan 15, 1999
• Grant date: Nov 5, 2002
• Expiry date: Jan 15, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/918
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective response to allergens.