Quinazoline derivatives as medicaments
US6476031B1 · kind B1 · utility
103Cited by
17References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 27, 1999 |
| Grant date | Nov 5, 2002 |
| Priority date | — |
| Expiry date | Aug 27, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to methods to inhibit TGF-&bgr; and/or p38-&agr; kinase using compounds of the formula or the pharmaceutically acceptable salts thereofwherein R3 is a noninterfering substituent;each Z is CR2 or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N;each R2 is independently a noninterfering substituent;L is a linker;n is 0 or 1; andAr′ is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.