Use of morphine derivatives as medicaments for the treatment of neuropathic problems

US6476044B1 · kind B1 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stephan Wnendt · Aachen, DE
• Wolfgang Strassburger · Würselen, DE
• Helmut Buschmann · Walheim, DE
• Elke Reiss-Mueller · Bielefeld, DE
• Thomas Krueger · Tilst, DK

Key dates

• Filing date: Feb 15, 2002
• Grant date: Nov 5, 2002
• Expiry date: Feb 15, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for agonizing or antagonizing the ORL1 (opioid receptor-like) receptor of the nociceptin/orphanin FQ ligand ORL1 receptor system using a morphinan compound of the general formula I or derivatives thereof. Also disclosed are methods for treating neuropathic pain and/or anxiolysis and/or depression and/or diuresis and/or urinary incontinence and/or hypotension and or hypertension and/or senile dementia and/or Alzheimer's disease and/or general cognitive disfunctions an/or tinnitus and/or impaired hearing and/or epilepsy and/or obesity and/or cachexia.