Patent · US Expired

N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

US6476077B1 · kind B1 · utility

2Cited by
1References
11Claims
0Family size

Assignee

Inventor

Key dates

Filing dateOct 2, 2001
Grant dateNov 5, 2002
Priority date—
Expiry dateOct 2, 2021

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C255/57
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A compound having the general formula (I): R1R2N—CH2CH2—CHAr1—CH2—NR3—CO—R4 wherein: R1 is hydrogen, C1-6 alkyl, C2-6 alkenyl, aryl, C1-6 alkanoyl C1-6 alkoxycarbonyl or arylcarbonyl; any of such groups being optionally substituted; R2 is hydrogen or C1-6 alkyl; or R1 or R2 are joined to form an optionally substituted morpholino ring; Ar1 is phenyl mono- or di-substituted by halo; R3 is hydrogen or C1-6 alkyl; R4 is optionally substituted naphth-1-yl; or pharmaceutically acceptable salts thereof. These compounds antagonize the pharmacological actions of the endogenous neuropeptide tachykinins, particularly the neurokinin 1 (NK1) receptor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.