Transgenic tilapia comprising a humanized insulin gene
US6476290B1 · kind B1 · utility
14Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2000 |
| Grant date | Nov 5, 2002 |
| Priority date | — |
| Expiry date | Jan 18, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2517/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using fish-preferred codons and regulatory sequences. These humanized genes are thus expressible in fish islet cells. Also provided are transgenic fish having islet cells containing and capable of expressing humanized insulin genes. These islet cells (Brockmann Bodies) can be xenotransplanted into subjects having diabetes. In this manner normoglycemia can be achieved in the recipient of the islets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.