Miniaturized fluid transfer device
US6478238B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2000 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Dec 24, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/1041
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A miniaturized ion sprayer device is suitable for coupling with chip-based analytical separation devices, multi-well plates, or surfaces containing residues of prepared samples. One embodiment, a “micro sprayer” device which is suitable for coupling to the terminal edge of a capillary electrophoresis (CE) chip is constructed from modified HPLC tubing and associated fittings and employs a free-standing liquid junction formed via continuous delivery of a flow (1-6 microliters/min) of suitable solvent which carries effluent through a pneumatically-assisted electrospray (ion spray) needle. A second embodiment employs the same features as the microsprayer, but with an extended sampling capillary tube which can reach into the depths of 96, 384, and 1,536 multi-well plates containing either sample solutions or dried sample residues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.