Process for the preparation of polymer-based sustained release compositions
US6479065B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 2001 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Mar 7, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1694
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions of the invention comprise a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer wherein the center and outer layer consist of essentially the same materials. The sustained release compositions can be prepared by annealing at least a substantial portion of the exterior surface of a polymer/active agent matrix. The compositions which have been annealed exhibit a decrease in the release of agent over the first 24 hours following administration (i.e., reduced burst) and as a result can show an increase in the duration of sustained release thereby providing increased therapeutic benefits.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.